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Here is a chart summarizing the main prescription, off-label, and over-the-counter (OTC) drugs approved or used for ADHD as of September 2025:

Drug CategoryDrug Name(s)Drug TypeFDA Approval Status for ADHDNotes
Prescription StimulantsMethylphenidate (Ritalin, Concerta), Amphetamines (Adderall, Vyvanse, Dexedrine)StimulantFDA-approvedFirst-line treatments that increase dopamine and norepinephrine levels in the brain.
Prescription Non-stimulantsAtomoxetine (Strattera), Guanfacine (Intuniv), Clonidine (Kapvay), ViloxazineNon-stimulantFDA-approvedOptions for patients who do not tolerate stimulants; affect norepinephrine or alpha-2 receptors.
Emerging Prescription DrugCentanafadineNon-stimulant (NDSRI)Under FDA review (Phase 3 trials)Affects dopamine, norepinephrine, and serotonin; low abuse potential; phase 3 trial positive.
Off-label DrugsModafinil (Provigil), Armodafinil (Nuvigil), Bupropion, Tricyclic AntidepressantsVariousNot FDA-approved for ADHDUsed off-label to improve focus and energy; lower abuse potential than stimulants.
Over-the-Counter (OTC)Caffeine, amino acids, antioxidants, iron, zinc supplementsSupplementsNot FDA-approved for ADHDMay help ease symptoms or complement prescription meds, but not substitute for them.

REMINDER: Not everyone with ADHD needs to take pharmaceuticals.



Disclaimer: Our content is for educational and informational purposes only and is not a substitute for professional advice. While we strive for accuracy, errors or omissions may occur. Content may be generated with artificial intelligence tools, which can produce inaccuracies. Readers are encouraged to verify information independently. In some situations, the information offered may lead to unintended or negative consequences. THIS CHART HAS NOT BEEN MEDICALLY REVIEWED.


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