Current evidence (2023) suggests that the majority of children and adults with Attention-Deficit/Hyperactivity Disorder (ADHD) will respond to at least one form of stimulant medication, which is the first-line treatment. For pediatric populations, studies show that approximately 70-80% of children with ADHD respond positively to stimulant therapy. Different individual responses to different medications or dosages make it more likely that a successful therapy can be identified for most children in this medication class. In adults, it’s estimated that between 58-70% have a positive response to stimulant therapy. It’s worth noting that treatment response in adults might be influenced by factors such as comorbidity and the presence of substance abuse disorders. Non-stimulant medication, often used when stimulants are not effective or tolerated, also show a fair response rate. For instance, atomoxetine, a non-stimulant medication, typically shows around a 55-64% response rate in children and 40-56% in adults. These statistics underscore that while ADHD medications are often effective, not all individuals with ADHD will respond to the first tried medication, and it’s essential to have a comprehensive approach to treatment. Optimizing treatment often requires tailoring the drug type and dosage to the individual’s unique symptom profile, age, comorbidities, side effect profile, and treatment response. It should also be noted that medication is often most effective when used in conjunction with behavioral therapies and lifestyle modifications.